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Data availability The cryo-EM maps have been deposited in the Electron Microscopy Data Bank (EMDB) under the accession codes EMD-71735 (OCTN2 inward-facing), EMD-71540 (OCTN2 occluded) and EMD-71597 (OCTN2 ipratropium)

Notably, these authors included in their analysis only randomized controlled trials with a duration 52 weeks considering that interventions shorter than that were unlikely to affect the fracture risk [13]

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